Effects of the disease
In rabbits of the genus Sylvilagus (cottontail rabbits), myxomatosis only causes localized skin tumors, but the European rabbit (Oryctolagus cuniculus) is more severely affected. It is crucial to prevent the misdiagnosis of myxomatosis with Pasteurellosis. Pasteurellosis  is a bacterial infection which can be treated with antibiotics. Rabbits treated for Pasteurellosis must often be treated with antibiotics for several weeks to several months. Some rabbits may require surgical intervention in order to remove purulent tissues and abscess.  Once Pasteurellosis has become well entrenched, however, there is no guarantee the animal will survive. By contrast, at this writing, there is no treatment for rabbits suffering Myxomatosis, other than palliative care to ease the suffering of individual animals, and the treatment for secondary and opportunistic infections , in the hopes the treated animal will survive. Though the vectors of communication are similar, either contact with an infected animal, cage, feeding or water dishes, and insects, it should be noted, also, that Pasteurellosis can also be spread through breeding, specifically infecting the sexual organs of the animal.  Likewise, it is advisable to arrive at the correct diagnosis for the benefit of both rabbit and owner. In cases of Myxomatosis and rabbit hemorrhagic disease (RHD) the owner is often urged to euthanize the animal to ease its suffering. Often the difference between diagnosing a fatal viral infection and a complex, but treatable bacterial infection, like Pasteurellosis, will likely include medications, X-rays, surgery, convalescent and, follow-up care. While surgery and antibiotics may successfully treat Pasteurellosis, they will not treat Myxomatosis or RHD. The owner and attending veterinarian must quickly discern between untreatable diseases and treatable conditions. Myxomatosis and RHD are highly communicable, and untreatable at any stage, whereas rabbits suffering from diseases/conditions other than Myxomatosis and RHD, such as poisoning, heat exhaustion, E. coli or Clostridium perfringens type E enterotoxemia can benefit from timely veterinary intervention.
Myxomatosis: At first, normally the disease is visible by lumps (myxomata) and puffiness around the head and genitals. It then may progress to acute conjunctivitis and possibly blindness; however, this also may be the first indication of the disease. The rabbits become listless, lose appetite, and develop a fever. Secondary bacterial infections occur in most cases which cause pneumonia and purulent inflammation of the lungs. In typical cases where the rabbit has no resistance death may take place with frightening rapidity, often in as little as 48 hrs. Death takes an average of 14 days.
Spread of the disease
In Australia, the virus was first field-tested for population control in 1938. A full-scale release was performed in 1950. It was devastatingly effective, reducing the estimated rabbit population from 600 million to 100 million in two years. However, the rabbits remaining alive were those least affected by the disease. Genetic resistance to myxomatosis was observed soon after the first release and most rabbits acquired partial immunity in the first two decades. Resistance has been increasing slowly since the 1970s, and the disease now only kills about 50% of infected rabbits. In an attempt to increase that number, a second virus (rabbit calicivirus) was introduced into the rabbit population in 1996.
Myxomatosis was unintentionally introduced to France by the bacteriologist Dr. Paul Armand Delille, following his use of the virus to rid his private estate of rabbits in June 1952 (controversially, he inoculated two of the rabbits on his land). Within four months the virus had spread 50 km; Armand suspected this was due to poachers taking infected rabbits from his estate. By 1954, 90% of the wild rabbits in France were dead. The disease spread throughout Europe. It reached the UK in 1953, apparently without human action. Some in the UK deliberately spread the disease, placing sick rabbits in burrows, while many others deplored the cruelty and suffering. The government refused to legislate to make deliberate spread of the disease illegal. By 1955, about 95% of rabbits in the UK were dead. Rabbits suffering in the last stages of the disease, commonly called "mixy" or "myxie" rabbits, are still a common sight in the UK. Unfortunately, the disease has wider consequences, apart from the death of rabbits: the Spanish Lynx among others is now almost extinct because the declining rabbit population, encompassing 90% of its diet, has caused mass starvation. It is not uncommon for shooters to specifically target infected rabbits, viewing the act as being merciful. In 2005 the UK Land Registry conducted a survey of 16,000 hectares of its land and reported that the rabbit population had increased 3 fold every two years.
Myxomatosis is spread by direct contact with an affected animal or by being bitten by fleas or mosquitoes that have fed on an infected rabbit. The myxomatosis virus does not replicate in these insect hosts, but can be physically carried by an insect's mouthparts, i.e. from an infected rabbit to another susceptible animal. Due to the potential of insect vector transmission, pet rabbits may be susceptible in enzootic areas and vaccination is highly recommended.
Use of vaccine
A vaccine is available for pet rabbits (ATCvet code: QI08), but is illegal in Australia due to fears that the immunity conferred by the vaccine could be transmitted through the wild rabbit population, since the vaccine uses a live virus, the Shope fibroma virus.
The development of resistance to the disease seems to have taken different courses. In Australia, the virus initially killed rabbits very quickly, about 4 days after infection. This gave little time for the infection to spread. However, a less virulent form of the virus has become prevalent there, spreading more effectively by being less lethal. In Europe, many rabbits are genetically resistant to the original virus that was spread. The survival rate of diseased rabbits has now increased to 35% when in the 1950s it was zero. It is conjectured that this is because the main transmission vector in Australia is the mosquito, while in Europe it is the rabbit flea.